Nicotine metabolism primarily can take area while in the liver. For that reason, when nicotine is administered throughout the GI method, it undergoes first-pass metabolism through the liver, leading to a bioavailability of only about twenty%. This method inherently decreases the bioavailability of nicotine within the process and could lead to adverse GI results.
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[seven] The addition of slaked lime and catechu to tobacco increases the absorption of nicotine from the oral cavity.
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